Novel Approaches to NMR and MRI

We pursue novel approaches to NMR and MRI, as well as application of these techniques in both the physical and life sciences. Our current research activities include nano- and micron-scale NMR and MRI using quantum defects in diamond.

In partnership with the group of Matthew Rosen, we developed an open-access, low-magnetic-field human MRI instrument, which allows studies of: (i) traumatic brain injury (TBI); (ii) molecular imaging using hyperpolarized nanoparticles and other media created by dynamic nuclear polarization (DNP); and (iii) pulmonary physiology using inhaled hyperpolarized noble gas (3He and 129Xe). We also investigate the creation and application of novel spin states in biomolecules, such as long-lived nuclear spin singlet states and coherences between singlet and triplet states.

Our NMR and MRI investigations are performed in the Walsworth Lab at the Center for Astrophysics and the Low-Field Imaging (LFI) Lab at the Martinos Center for Biomedical Imaging.

 

High-Resolution NMR Spectroscopy Using Quantum Diamond Sensors


Left: NV ensemble in diamond serves as a high-spectral-resolution NMR sensor for samples at the scale of a single cell (~10 microns). Right: NV-NMR spectrum of xylene provides chemical information at the micron-scale.

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